产品货号：
Z24266
中文名称：
PRKG1抗体
英文名称：
Anti-PRKG1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRKG1 Antibody |
| 指标别名 | cGK 1;cGK1;CGKI;cGKI alpha;cGKI BETA;PGK;PKG;PRKG1;PRKG1B;PRKGR1A;PRKGR1B;Protein Kinase G1 alpha |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | PRKG1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human cGKI/PRKG1 recombinant protein (Position:S2-Q44). |
| 实际分子量 | 78KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | cGMP-dependent protein kinase 1,alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha,Ibeta,and II).These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types.This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing.A separate gene on human chromosome 4,PRKG2,encodes the membrane-bound PRKG isoform II.The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone,preventing platelet aggregation,and modulating cell growth.This gene is most strongly expressed in all types of smooth muscle,platelets,cerebellar Purkinje cells,hippocampal neurons,and the lateral amygdala.Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. |
| Uniprot ID | Q13976 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | protein kinase cGMP-dependent 1 |
| 蛋白名全称 | cGMP-dependent protein kinase 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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